Healthcare LLM refers to a specialized large language model designed to optimize healthcare workflows through explainable reasoning and safe data generation. It assists with complex tasks like diagnostics, treatment planning, and patient management across multiple data modalities, such as text, images, and structured data.

The Healthcare Large Multimodal Models Project emphasizes transparency and safety, ensuring healthcare professionals can trust AI’s decisions. This will lead to improved efficiency, reduced errors, and enhanced patient outcomes across healthcare systems.

Posts

Monitoring AI-Modified Content at Scale: A Case Study on the Impact of ChatGPT on AI Conference Peer Reviews

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We present an approach for estimating the fraction of text in a large corpus which is likely to be substantially modified or produced by a large language model (LLM). Our maximum likelihood model leverages expert-written and AI-generated reference texts to accurately and efficiently examine real-world LLM-use at the corpus level. We apply this approach to a case study of scientific peer review in AI conferences that took place after the release of ChatGPT: ICLR 2024, NeurIPS 2023, CoRL 2023 and EMNLP 2023. Our results suggest that between 6.5% and 16.9% of text submitted as peer reviews to these conferences could have been substantially modified by LLMs, i.e. beyond spell-checking or minor writing updates. The circumstances in which generated text occurs offer insight into user behavior: the estimated fraction of LLM-generated text is higher in reviews which report lower confidence, were submitted close to the deadline, and from reviewers who are less likely to respond to author rebuttals. We also observe corpus-level trends in generated text which may be too subtle to detect at the individual level, and discuss the implications of such trends on peer review. We call for future interdisciplinary work to examine how LLM use is changing our information and knowledge practices.

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Evaluating Cellularity Estimation Methods: Comparing AI Counting with Pathologists’ Visual Estimates

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The development of next-generation sequencing (NGS) has enabled the discovery of cancer-specific driver gene alternations, making precision medicine possible. However, accurategenetic testing requires a sufficient amount of tumor cells in the specimen. The evaluation of tumor content ratio (TCR) from hematoxylin and eosin (H&E)-stained images has been found to vary between pathologists, making it an important challenge to obtain an accurate TCR. In this study, three pathologists exhaustively labeled all cells in 41 regions from 41 lung cancer cases as either tumor, non-tumor or indistinguishable, thus establishing a “gold standard” TCR. We then compared the accuracy of the TCR estimated by 13 pathologists based on visual assessment and the TCR calculated by an AI model that we have developed. It is a compact and fast model that follows a fully convolutional neural network architecture and produces cell detection maps which can be efficiently post-processed to obtain tumor and non-tumor cell counts from which TCR is calculated. Its raw cell detection accuracy is 92% while its classification accuracy is 84%. The results show that the error between the gold standard TCR and the AI calculation was significantly smaller than that between the gold standard TCR and the pathologist’s visual assessment (p < 0.05). Additionally, the robustness of AI models across institutions is a key issue and we demonstrate that the variation in AI was smallerthan that in the average of pathologists when evaluated by institution. These findings suggest that the accuracy of tumor cellularity assessments in clinical workflows is significantly improved by the introduction of robust AI models, leading to more efficient genetic testing and ultimately to better patient outcomes.

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Improving Test-Time Adaptation For Histopathology Image Segmentation: Gradient-To-Parameter Ratio Guided Feature Alignment

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In the field of histopathology, computer-aided systems face significant challenges due to diverse domain shifts. They include variations in tissue source organ, preparation and scanningprotocols. These domain shifts can significantly impact algorithms’ performance in histopathology tasks, such as cancer segmentation. In this paper, we address this problem byproposing a new multi-task extension of test-time adaptation (TTA) for simultaneous semantic, and instance segmentation of nuclei. First, to mitigate domain shifts during testing, weuse a feature alignment TTA method, through which we adapt the feature vectors of the target data based on the feature vectors’ statistics derived from the source data. Second, the ratioof Gradient norm to Parameter norm (G2P) is proposed to guide the feature alignment procedure. Our approach requires a pre-trained model on the source data, without requiringaccess to the source dataset during TTA. This is particularly crucial in medical applications where access to training data may be restricted due to privacy concerns or patient consent. Through experimental validation, we demonstrate that the proposed method consistently yields competitive results when applied to out-of-distribution data across multiple datasets.

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Strategic Preys Make Acute Predators: Enhancing Camouflaged Object Detectors by Generating Camouflaged Objects

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Camouflaged object detection (COD) is the challenging task of identifying camouflaged objects visually blended into surroundings. Albeit achieving remarkable success, existing COD detectors still struggle to obtain precise results in some challenging cases. To handle this problem, we draw inspiration from the prey-vs-predator game that leads preys to develop better camouflage and predators to acquire more acute vision systems and develop algorithms from both the prey side and the predator side. On the prey side, we propose an adversarial trainingframework, Camouflageator, which introduces an auxiliary generator to generate more camouflaged objects that are harder for a COD method to detect. Camouflageator trains the generator and detector in an adversarial way such that the enhanced auxiliary generator helps produce a stronger detector. On the predator side, we introduce a novel COD method, called Internal Coherence and Edge Guidance (ICEG), which introduces a camouflaged feature coherence module to excavate the internal coherence of camouflaged objects, striving to obtain morecomplete segmentation results. Additionally, ICEG proposes a novel edge-guided separated calibration module to remove false predictions to avoid obtaining ambiguous boundaries. Extensive experiments show that ICEG outperforms existing COD detectors and Camouflageator is flexible to improve various COD detectors, including ICEG, which brings state-of-the-art COD performance.

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Provable Membership Inference Privacy

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In applications involving sensitive data, such as finance and healthcare, the necessity for preserving data privacy can be a significant barrier to machine learning model development.Differential privacy (DP) has emerged as one canonical standard for provable privacy. However, DP’s strong theoretical guarantees often come at the cost of a large drop in its utility for machine learning; and DP guarantees themselves are difficult to interpret. In this work, we propose a novel privacy notion, membership inference privacy (MIP), as a steptowards addressing these challenges. We give a precise characterization of the relationship between MIP and DP, and show that in some cases, MIP can be achieved using less amountof randomness compared to the amount required for guaranteeing DP, leading to smaller drop in utility. MIP guarantees are also easily interpretable in terms of the success rate of membership inference attacks in a simple random subsampling setting. As a proof of concept, we also provide a simple algorithm for guaranteeing MIP without needing to guarantee DP.

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Weakly-supervised Concealed Object Segmentation with SAM-based Pseudo Labeling and Multi-scale Feature Grouping

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Weakly-Supervised Concealed Object Segmentation (WSCOS) aims to segment objects well blended with surrounding environments using sparsely-annotated data for model training. It remains a challenging task since (1) it is hard to distinguish concealed objects from the background due to the intrinsic similarity and (2) the sparsely-annotated training data only provide weak supervision for model learning. In this paper, we propose a new WSCOS method to address these two challenges. To tackle the intrinsic similarity challenge, we design a multi-scalefeature grouping module that first groups features at different granularities and then aggregates these grouping results. By grouping similar features together, it encourages segmentation coherence, helping obtain complete segmentation results for both single and multiple-object images. For the weak supervision challenge, we utilize the recently-proposed vision foundation model, “Segment Anything Model (SAM)”, and use the provided sparse annotations as prompts to generate segmentation masks, which are used to train the model. To alleviate the impact oflow-quality segmentation masks, we further propose a series of strategies, including multi-augmentation result ensemble, entropy-based pixel-level weighting, and entropy-based image-level selection. These strategies help provide more reliable supervision to train the segmentation model. We verify the effectiveness of our method on various WSCOS tasks, and experiments demonstrate that our method achieves state-of-the-art performance on these tasks.

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Personalized Semantics Excitation for Federated Image Classification

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Federated learning casts a light on the collaboration of distributed local clients with privacy protected to attain a more generic global model. However, significant distribution shift in input/label space across different clients makes it challenging to well generalize to all clients, which motivates personalized federated learning (PFL). Existing PFL methods typically customize the local model by fine-tuning with limited local supervision and the global model regularizer, which secures local specificity but risks ruining the global discriminative knowledge. In this paper, we propose a novel Personalized Semantics Excitation (PSE) mechanism to breakthrough this limitation by exciting and fusing personalized semantics from the global model during local model customization. Specifically, PSE explores channel-wise gradient differentiation across global and local models to identify important low-level semantics mostly from convolutional layers which are embedded into the client-specific training.In addition, PSE deploys the collaboration of global and local models to enrich high-level feature representations and facilitate the robustness of client classifier through a cross-model attention module. Extensive experiments and analysis on various image classification benchmarks demonstrate the effectiveness and advantage of our method over the state-of-the-art PFL methods.

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MSI: Maximize Support-Set Information for Few-Shot Segmentation

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Few-Shot Segmentation FSS (Few-shot segmentation) aims to segment a target class using a small number of labeled images (support set). To extract information relevant to the target class, a dominant approach in best performing FSS methods removes background features using a support mask. We observe that this feature excision through a limiting support mask introduces an information bottleneck in several challenging FSS cases, e.g., for small targets and/or inaccurate target boundaries. To this end, we present a novel method (MSI), which maximizes the support-set information by exploiting two complementary sources of features to generate super correlation maps. We validate the effectiveness of our approach by instantiating it into three recent and strong FSS methods. Experimental results on several publicly available FSS benchmarks show that our proposed method consistently improves performance by visible margins and leads to faster convergence.

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Degradation-Resistant Unfolding Network for Heterogeneous Image Fusion

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Heterogeneous image fusion (HIF) aims to enhance image quality by merging complementary information of images captured by different sensors. Early model-based approaches have strong interpretability while being limited by non-adaptive feature extractors with poor generalizability.

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Automatically Evaluating Opinion Prevalence in Opinion Summarization

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When faced with a large number of product reviews, it is not clear that a human can remember all of them and weight opinions representatively to write a good reference summary. Wepropose an automatic metric to test the prevalence of the opinions that a summary expresses, based on counting the number of reviews that are consistent with each statement in the summary, while discrediting trivial or redundant statements. To formulate this opinion prevalence metric, we consider several existing methods to score the factual consistency of a summary statement with respect to each individual source review. On a corpus of Amazon product reviews, we gather multiple human judgments of the opinion consistency, to determinewhich automatic metric best expresses consistency in product reviews. Using the resulting opinion prevalence metric, we show that a human authored summary has only slightly betteropinion prevalence than randomly selected extracts from the source reviews, and previous extractive and abstractive unsupervised opinion summarization methods perform worse thanhumans. We demonstrate room for improvement with a greedy construction of extractive summaries with twice the opinion prevalence achieved by humans. Finally, we show that pre-processing source reviews by simplification can raise the opinion prevalence achieved by existing abstractive opinion summarization systems to the level of human performance

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