MACHINE LEARNING
PROJECTS
PEOPLE
PUBLICATIONS
PATENTS
Machine Learning
Martin Renqiang Min is the Department Head of the Machine Learning Department at NEC Laboratories America. He holds a Ph.D. in Computer Science from the University of Toronto and completed postdoctoral research at Yale University, where he also taught courses on deep learning. His research has been published in top venues, including Nature, NeurIPS, ICML, ICLR, CVPR, and ACL, and his innovations have been recognized internationally, with features in Science and MIT Technology Review.
At NEC, Dr. Min directs a multidisciplinary research team at the forefront of foundational and applied artificial intelligence. His portfolio spans deep learning, natural language understanding, multimodal learning, visual reasoning, and the application of machine learning to biomedical and healthcare data. He has contributed to the design of scalable learning systems that power real-world applications, bridging cutting-edge theory with industry-scale deployment. He also co-chaired the NeurIPS Workshop on Machine Learning in Computational Biology, advancing the dialogue between AI and life sciences.
Under his leadership, NEC’s machine learning group drives innovation across multiple domains, including AI for precision medicine, next-generation language modeling, and interpretable multimodal systems. He is known for fostering interdisciplinary collaboration—both within NEC and with academic and industry partners—encouraging research that connects scientific breakthroughs with societal impact. His team’s contributions extend to core technologies used across telecommunications, enterprise solutions, and healthcare, positioning NEC at the leading edge of applied AI. Dr. Min is recognized for his ability to identify emerging trends in machine learning and translate them into long-term research roadmaps. His work continues to influence the global AI community, and his leadership ensures NEC remains a hub for transformative research that combines fundamental discovery with practical applications that improve people’s lives.
Overview: We are focused on developing advanced LMMs that integrate explainable reasoning and safe generation to optimize healthcare workflows. These models are designed to process and analyze multiple data modalities—such as text, images, and structured data—enabling them to assist in complex tasks like diagnostics, treatment planning, and patient management with exceptional accuracy.
Overview: This research project is at the forefront of integrating advanced Large Language Models (LLMs) into the process of deriving actionable insights from vast and complex document repositories. This initiative focuses on creating a system that allows users to interact with the LLM, guiding its analysis and refining the results based on the user’s expertise and evolving needs.
Overview: Since 2019, the parameters of large deep learning models have increased by over 300 times every 18 months. However, the future ML progress cannot continue simply based on using more data or creating larger models, because the growing gap between the model demand and resource supply is not sustainable.
Overview: We have developed a system for real-time scene understanding and reasoning across various domains such as safety, manufacturing, retail, healthcare, and personal assistance. This system continuously monitors and analyzes video, acoustics, and time series data related to human activities, aiming to provide a comprehensive understanding of ongoing situations. The project utilizes advanced AI models to process large volumes of data, generating actionable insights that help users grasp complex scenarios.
Overview: Our research spans many areas of text understanding and text generation, with a particular emphasis on factuality checking and factually guided text generation. NEC’s products help humans safely draw conclusions from large quantities of text that they don’t have the time to read. As a leader in the FEVER fact extraction and verification competitions, we have developed systems that achieved higher evidence precision and higher robustness to adversarial attack, and pioneered the ability to pursue missing evidence through multiple retrieval steps.
Overview: The Trustworthy Generative AI Project is focused on developing advanced multimodal generative models that can create and reason with content across text, images, reports, and 3D videos. These models are designed for applications in advertisement, entertainment, law enforcement, and healthcare.
Recent advances in video diffusion models have enabled the generation of high-quality videos. However, these videos still suffer from unrealistic deformations, semantic violations, and physical inconsistencies that are largely rooted in the absence of 3D physical priors. To address these challenges,
State-of-the-art video models are accurate but too slow for live deployment. This work transfers their knowledge into causal streaming models that process video frames in real time, achieving 4x lower latency with competitive accuracy across action detection and pedestrian intent tasks.
Diffusion models (DMs) have proven to be effective in modeling high-dimensional distributions, leading to their widespread adoption for representing complex priors in Bayesian inverse problems (BIPs). However, current DM-based posterior sampling methods proposed for solving common BIPs rely on heuristic
Designing drug molecules is no longer just about generation, but control. NEC Laboratories America introduces MolDiffdAE, a diffusion-based framework that enables precise, multi-objective tuning of 3D molecular properties. By learning a semantic space, researchers can efficiently guide design, accelerating
Clinical diagnosis requires sequential evidence acquisition under uncertainty. However, most Large Language Model (LLM) based diagnostic systems assume fully observed patient information and therefore do not explicitly model how clinical evidence should be sequentially acquired over time. Even when diagnosis
Controlled generation of 3D molecules is highly valuable in drug design, enabling targeted modifications that preserve core structure and binding-relevant geometry while improving developability-related properties. While equivariant diffusion models achieve state-of-the-art de novo 3D molecule generation,
Vision Transformers (ViTs) have achieved state-of-the-art performance in offline video action detection, but their reliance on processing fixed-size clips with full spatio-temporal attention makes them computationally expensive and ill-suited for real-time streaming applications due to massive computational
Recent advances in video diffusion models have enabled the generation of high-quality videos. However, these videos still suffer from unrealistic deformations, semantic violations, and physical inconsistencies that are largely rooted in the absence of 3D physical priors. To address these challenges,
Radiology report generation requires advanced medical image analysis, effective temporal reasoning, and accurate text generation. Although recent innovations, particularly multimodal large language models, have shown improved performance, their supervised fine-tuning (SFT) objective is not explicitly
Large Language Models (LLMs) have demonstrated remarkable capabilities in understanding and generating human-like text, yet they largely operate as reactive agents, responding only when directly prompted. This passivity creates an “awareness gap,” limiting their potential as truly collaborative partners
Cell fate decisions are highly coordinated processes governed bycomplex interactions among numerous regulatory genes, whiledisruptions in these mechanisms can lead to developmental abnormalitiesand disease. Traditional methods often fail to capture suchcombinatorial interactions, limiting their ability
Adapting large Video-Language Models (VLMs) for action detection using only a few examples poses challenges like overfitting and the granularity mismatch between scene-level pre-training and required person-centric understanding. We propose an efficient adaptation strategy combining parameter-efficient
Designing protein-binding proteins with high affinity is critical in biomedical research and biotechnology. Despite recent advancements targeting specific proteins, the ability to create high-affinity binders for arbitrary protein targets on demand, without extensive rounds of wet-lab testing,remains
Diffusion models (DMs) have proven to be effective in modeling high-dimensional distributions, leading to their widespread adoption for representing complex priors in Bayesian inverse problems (BIPs). However, current DM-based posterior sampling methods proposed for solving common BIPs rely on heuristic
Multi-camera multi-object tracking (MCMOT) faces significant challenges in maintaining consistent object identities across varying camera perspectives, particularly when precise calibration and extensive annotations are required. In this paper, we present CalibFree, a self-supervised representation learning
Despite the recent impressive breakthroughs in text-to-image generation, generative models have difficulty in capturing thedata distribution of underrepresented attribute compositions while over-memorizing overrepresented attribute compositions,which raises public concerns about their robustness and
We consider the conditional generation of 3D drug-like molecules with explicit control over molecular properties such as drug-like properties (e.g., Quantitative Estimate of Druglikenessor Synthetic Accessibility score) and effectively binding to specific protein sites. To tackle this problem, we propose
Our NEC Lab America team attended the Thirty-Ninth AAAI Conference on Artificial Intelligence (AAAI-25), in Philadelphia, Pennsylvania at the Pennsylvania Convention Center from February 25 to March 4, 2025. The purpose of the AAAI conference series was to promote research in AI and foster scientific
Multimodal Large Language Models (MLLMs) have shown impressive performance in vision and text tasks. However, hallucination remains a major challenge, especially in fields like healthcare where details are critical. In this work, we show how MLLMs may be enhanced to support Visual RAG (V-RAG), a retrieval-augmented
Variational optimization (VO) offers a general approach for handling objectives which may involve discontinuities, or whose gradients are difficult to calculate. By introducing a variational distribution over the parameter space, such objectives are smoothed, and rendered amenable to VO methods. Local
Transcriptional regulation through cis-regulatory elements (CREs) is crucial for numerous biological functions, with its disruption potentially leading to various diseases. It is well-known that these CREs often exhibit redundancy, allowing them to compensate for each other in response to external
NEC Labs America is proud to attend NeurIPS 2024 in Vancouver, Canada from December 10-15. Zachary Izzo will present Subgroup Discovery with the Cox Model, Shaobo Han will present VB-LoRA: Extreme Parameter Efficient Fine-Tuning with Vector Banks and Jonathan Warrell will present Discrete-Continuous
Levels of selection and multilevel evolutionary processes are essential concepts in evolutionary theory, and yet there is a lack of common mathematical models for these core ideas. Here, we propose a unified mathematical framework for formulating and optimizing multilevel evolutionary processes and genetic
When performing complex multi-step reasoning tasks, the ability of Large Language Models (LLMs) to derive structured intermediate proof steps is important for ensuring that the models truly perform the desired reasoning and for improving models’ explainability. This paper is centered around a focused
Learning to localize temporal boundaries of procedure steps in instructional videos is challenging due to the limited availability of annotated large-scale training videos. Recent works focus on learning the cross-modal alignment between video segments and ASR-transcripted narration texts through contrastive
Spatial transcriptomics technologies, which generate a spatial map of gene activity, can deepen the understanding of tissue architecture and its molecular underpinnings in health and disease. However, the high cost makes these technologies difficult to use in practice. Histological images co-registered
We are thrilled to announce the launch of our latest research initiative, the Trustworthy Generative AI Project. This ambitious project is set to revolutionize how we interact with multimodal content by developing cutting-edge generative models capable of compositional generation and reasoning across
In this paper, we introduce efforts to apply large language models (LLMs) to the field of material development. NEC is advancing the development of a material development platform. By applying core technologies corresponding to two material development steps, namely investigation activities (Read paper/patent)
Weakly Supervised Temporal Action Localization (WSTAL) aims to jointly localize and classify action segments in untrimmed videos with only video level annotations. To leverage video level annotations most existing methods adopt the multiple instance learning paradigm where frame/snippet level action
In this paper we explore the capability of an agent to construct a logical sequence of action steps thereby assembling a strategic procedural plan. This plan is crucial for navigating from an initial visual observation to a target visual outcome as depicted in real-life instructional videos. Existing
Our team will be attending CVPR 2024 (The IEEE /CVF Conference on Computer Vision & Pattern Recognition) from June 17-21! See you there at the NEC Labs America Booth 1716! Stay tuned for more information about our participation.
Motivation Spatial transcriptomics technologies, which generate a spatial map of gene activity, can deepen the understanding of tissue architecture and its molecular underpinnings in health and disease. However, the high cost makes these technologies difficult to use in practice. Histological images
Recent advances in spatial transcriptomics allow spatially resolved gene expression measurements with cellular or even sub-cellular resolution, directly characterizing the complex spatiotemporal gene expression landscape and cell-to-cell interactions in their native microenvironments. Due to technology
In protein biophysics, the separation between the functionally important residues (forming the active site or binding surface) and those that create the overall structure (the fold) is a well-established and fundamental concept. Identifying and modifying those functional sites is critical for protein
Recent few-shot video classification (FSVC) works achieve promising performance by capturing similarity across support and query samples with different temporal alignment strategies or learning discriminative features via Transformer block within each episode. However, they ignore two important issues:
Source-free domain adaptation (SFDA) is an emerging research topic that studies how to adapt a pretrained source model using unlabeled target data. It is derived from unsupervised domain adaptation but has the advantage of not requiring labeled source data to learn adaptive models. This makes it particularly
Conditional image-to-video (cI2V) generation aims to synthesize a new plausible video starting from an image (e.g., a person’s face) and a condition (e.g., an action class label like smile). The key challenge of the cI2V task lies in the simultaneous generation of realistic spatial appearance and temporal
Diffusion probabilistic models have achieved enormous success in the field of image generation and manipulation. In this paper, we explore a novel paradigm of using the diffusion model and classifier guidance in the latent semantic space for compositional visual tasks. Specifically, we train latent diffusion
T cells monitor the health status of cells by identifying foreign peptides displayed on their surface. T-cell receptors (TCRs), which are protein complexes found on the surface of T cells, are able to bind to these peptides. This process is known as TCR recognition and constitutes a key step for immune
Motivation: MHC Class I protein plays an important role in immunotherapy by presenting immunogenic peptides to anti-tumor immune cells. The repertoires of peptides for various MHC Class I proteins are distinct, which can be reflected by their diverse binding motifs. To characterize binding motifs for
Several recent studies investigate TCR-peptide/-pMHC binding prediction using machine learning or deep learning approaches. Many of these methods achieve impressive results on test sets, which include peptide sequences that are also included in the training set. In this work, we investigate how state
We present a multi-sequence generalization of Variational Information Bottleneck and call the resulting model Attentive Variational Information Bottleneck (AVIB). Our AVIB model leverages multi-head self-attention to implicitly approximate a posterior distribution over latent encodings conditioned on
Predicting the interactions between T-cell receptors (TCRs) and peptides is crucial for the development of personalized medicine and targeted vaccine in immunotherapy. Current datasets for training deep learning models of this purpose remain constrained without diverse TCRs and peptides. To combat the
Although progress has been made for text-to-image synthesis, previous methods fall short of generalizing to unseen or underrepresented attribute compositions in the input text. Lacking compositionality could have severe implications for robustness and fairness, e.g., inability to synthesize the face
We propose a reinforcement learning-based approach to query object localization, for which an agent is trained to localize objects of interest specified by a small exemplary set. We learn a transferable reward signal formulated using the exemplary set by ordinal metric learning. Our proposed method enables
StyleGANs have shown impressive results on data generation and manipulation in recent years, thanks to its disentangled style latent space. A lot of efforts have been made in inverting a pretrained generator, where an encoder is trained ad hoc after the generator is trained in a two-stage fashion. In
Molecule optimization is a critical step in drug development to improve the desired properties of drug candidates through chemical modification. We have developed a novel deep generative model, Modof, over molecular graphs for molecule optimization. Modof modifies a given molecule through the prediction
Image captioning systems are expected to have the ability to combine individual concepts when describing scenes with concept combinations that are not observed during training. In spite of significant progress in image captioning with the help of the autoregressive generation framework, current approaches
Conditional Generative Adversarial Networks (cGANs) extend the standard unconditional GAN framework to learning joint data-label distributions from samples, and have been established as powerful generative models capable of generating high-fidelity imagery. A challenge of training such a model lies in
Recent studies have demonstrated the vulnerability of deep neural networks against adversarial examples. In-spired by the observation that adversarial examples often lie outside the natural image data manifold and the intrinsic dimension of image data is much smaller than its pixel space dimension, we
MotivationMapping distal regulatory elements, such as enhancers, is a cornerstone for elucidating how genetic variations may influence diseases. Previous enhancer-prediction methods have used either unsupervised approaches or supervised methods with limited training data. Moreover, past approaches have
This paper considers the problem of spatiotemporal object-centric reasoning in videos. Central to our approach is the notion of object permanence, i.e., the ability to reason about the location of objects as they move through the video while being occluded, contained or carried by other objects. Existing
Learning disentangled representations leads to interpretable models and facilitates data generation with style transfer, which has been extensively studied on static data such as images in an unsupervised learning framework. However, only a few works have explored unsupervised disentangled sequential
T-cell receptors can recognize foreign peptides bound to major histocompatibility complex (MHC) class-I proteins, and thus trigger the adaptive immune response. Therefore, identifying peptides that can bind to MHC class-I molecules plays a vital role in the design of peptide vaccines. Many computational
Deep neural networks have been widely applied for missing data imputation. However, most existing studies have been focused on imputing continuous data, while discrete data imputation is under-explored. Discrete data is common in real world, especially in research areas of bioinformatics, genetics, and
Learning disentangled representations of natural language is essential for many NLP tasks, e.g., conditional text generation, style transfer, personalized dialogue systems, etc. Similar problems have been studied extensively for other forms of data, such as images and videos. However, the discrete nature
We propose a sequential variational autoencoder to learn disentangled representations of sequential data (e.g., videos and audios) under self-supervision. Specifically, we exploit the benefits of some readily accessible supervision signals from input data itself or some off-the-shelf functional models
Recent developments in discovering dynamic treatment regimes (DTRs) have heightened the importance of deep reinforcement learning (DRL) which are used to recover the doctor’s treatment policies. However, existing DRL-based methods expose the following limitations: 1) supervised methods based on behavior
The rich and accessible labeled data fueled the revolutionary successes of deep learning in object recognition. However, recognizing objects of novel classes with limited supervision information provided, i.e., Novel Object Recognition (NOR), remains a challenging task. We identify in this paper two
Zero-shot learning (ZSL) aims to recognize instances of unseen classes solely based on the semantic descriptions of the classes. Existing algorithms usually formulate it as a semantic-visual correspondence problem, by learning mappings from one feature space to the other. Despite being reasonable, previous
Traditional embedding approaches associate a real-valued embedding vector with each symbol or data point, which is equivalent to applying a linear transformation to “one-hot” encoding of discrete symbols or data objects. Despite simplicity, these methods generate storage-inefficient representations
Developing conditional generative models for text-to-video synthesis is an extremely challenging yet an important topic of research in machine learning. In this work, we address this problem by introducing Text-Filter conditioning Generative Adversarial Network (TFGAN), a conditional GAN model with a
In spite of its importance, passenger demand prediction is a highly challenging problem, because the demand is simultaneously influenced by the complex interactions among many spatial and temporal factors and other external factors such as weather. To address this problem, we propose a Spatio-TEmporal
Recent studies have demonstrated the vulnerability of deep convolutional neural networks against adversarial examples. Inspired by the observation that the intrinsic dimension of image data is much smaller than its pixel space dimension and the vulnerability of neural networks grows with the input dimension,
Convolutional neural networks (CNNs) have recently emerged as a popular building block for natural language processing (NLP). Despite their success, most existing CNN models employed in NLP share the same learned (and static) set of filters for all input sentences. In this paper, we consider an approach
Parametric embedding methods such as parametric t-distributed Stochastic Neighbor Embedding (pt-SNE) enables out-of-sample data visualization without further computationally expensive optimization or approximation. However, pt-SNE favors small mini-batches to train a deep neural network but large mini-batches
Many deep learning architectures have been proposed to model the compositionality in text sequences, requiring substantial number of parameters and expensive computations. However, there has not been a rigorous evaluation regarding the added value of sophisticated compositional functions. In this paper,
Conventional embedding methods directly associate each symbol with a continuous embedding vector, which is equivalent to applying a linear transformation based on a one-hot encoding of the discrete symbols. Despite its simplicity, such approach yields the number of parameters that grows linearly
Unsupervised anomaly detection on multi- or high-dimensional data is of great importance in both fundamental machine learning research and industrial applications, for which density estimation lies at the core. Although previous approaches based on dimensionality reduction followed by density estimation
Generating videos from text has proven to be a significant challenge for existing generative models. We tackle this problem by training a conditional generative model to extract both static and dynamic information from text. This is manifested in a hybrid framework, employing a Variational Autoencoder
Previous models for video captioning often use the output from a specific layer of a Convolutional Neural Network (CNN) as video features. However, the variable context-dependent semantics in the video may make it more appropriate to adaptively select features from the multiple CNN layers. We propose