Data Perturbation refers to modifying datasets with controlled noise or transformations to improve model robustness or protect privacy. NECLA uses data perturbation in research on adversarial robustness, privacy-preserving AI, and resilient sensing. By perturbing data, researchers test how models adapt under stress, enhancing their ability to generalize. These methods ensure that deployed AI systems maintain security and reliability in real-world conditions, safeguarding performance against adversarial challenges.

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Identifying Combinatorial Regulatory Genes for Cell Fate Decision via Reparameterizable Subset Explanations

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Cell fate decisions are highly coordinated processes governed bycomplex interactions among numerous regulatory genes, whiledisruptions in these mechanisms can lead to developmental abnormalitiesand disease. Traditional methods often fail to capture suchcombinatorial interactions, limiting their ability to fully model cellfate dynamics. Here, we introduce MetaVelo, a global feature explanationframework for identifying key regulatory gene sets influencingcell fate transitions. MetaVelo models these transitions as ablack-box function and employs a differentiable neural ordinary differentialequation (ODE) surrogate to enable efficient optimization.By reparameterizing the problem as a controllable data generationprocess, MetaVelo overcomes the challenges posed by the nondifferentiablenature of cell fate dynamics. Benchmarking acrossdiverse stand-alone and longitudinal single-cell RNA-seq datasetsand three black-box cell fate models demonstrates its superiorityover 12 baseline methods in predicting developmental trajectoriesand identifying combinatorial regulatory gene sets. MetaVelo furtherdistinguishes independent from synergistic regulatory genes,offering novel insights into the gene interactions governing cellfate. With the growing availability of high-resolution single-celldata, MetaVelo provides a scalable and effective framework fo

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