Rethinking Molecular Drug Design: From Generation to Control

Designing drug molecules is no longer just about generation, but control. NEC Laboratories America introduces MolDiffdAE, a diffusion-based framework that enables precise, multi-objective tuning of 3D molecular properties. By learning a semantic space, researchers can efficiently guide design, accelerating drug discovery and exploration of chemical space.

Quantitative Bounds for Length Generalization in Transformers

We study the problem of length generalization (LG) in transformers: the ability of a model trained on shorter sequences to maintain performance when evaluated on much longer, previously unseen inputs. Prior work by Huang et al. (2024) established that transformers eventually achieve length generalization once the training sequence length exceeds some finite threshold, but left open the question of how large it must be. In this work, we provide the first quantitative bounds on the required training length for length generalization to occur. Motivated by previous empirical and theoretical work, we analyze LG in several distinct problem settings: error control vs. average error control over an input distribution, infinite-precision softmax attention vs. finite-precision attention (which reduces to an argmax) in the transformer, as well as for one- or two-layer transformers. In all scenarios, we prove that LG occurs when the internal behavior of the transformer on longer sequences can be “simulated” by its behavior on shorter sequences seen during training. Our bounds give qualitative estimates for the required length of training data required for a transformer to generalize, and we verify these insights empirically. These results sharpen our theoretical understanding of the mechanisms underlying extrapolation in transformers, and formalize the intuition that richer training data is required for generalization on more complex tasks.

Future of Cloud Computing with GenAI: Kunal Rao at Cloud Computing 2026

Generative AI is transforming cloud computing. At Cloud Computing 2026, Kunal Rao will chair the GenAI4Cloud track and deliver a keynote on software engineering in the AI era, exploring how AI agents, LLMs, and intelligent infrastructure are redefining the cloud stack.

Agentic Placement of Microservices on the Computing Continuum

Deploying microservices across the computing continuum (edge–cloud) requires placement decisions that adapt to workload variation and heterogeneous infrastructure, yet existing solutions often rely on static policies or opaque heuristics. We present Bellona a system for reliable and auditable Large Language Model (LLM)-driven workflow execution that combines a declarative specification language with a runtime that orchestrates tool calls, conditional control flow, and structured LLM reasoning. Using Bellona, we implement an agentic placement workflow that automatically recommends edge or cloud execution. The workflow uses structured prompts and verifiable tool interactions to (i) parse placement and latency-report instructions, (ii) update the latency log, and (iii) select placements based on measured latency improvement thresholds. We evaluate the resulting agent on two representative microservices-based video analytics applications (human-attributes detection and face recognition) over two days of varying workload. Across 1,440 placement decisions per service, the agent achieves accuracies of 94.66%/84.94% (human-attributes detection, Day1/Day2) and 80.91%/96.53% (face recognition, Day1/Day2) with GPT-4o; with GPT-5, accuracy increases to 98.82%/99.45% (human-attributes detection) and 99.31%/99.8% (face recognition). These results demonstrate that Bellona can support practical, self-improving agentic control for placement of microservices on the computing continuum.

Driving the Future of Scene Editing with HorizonForge

HorizonForge introduces a new approach to driving scene generation, enabling precise control over both vehicle behavior and identity. By allowing arbitrary trajectories and flexible vehicle insertion, it creates realistic, scalable simulations for autonomous driving, digital twins, and advanced AI development.

Eric C. Blow to Deliver Photonic AI Keynote at COOL Chips 29 in Tokyo on April 17th

Eric C. Blow of NEC Laboratories America presents a keynote at COOL Chips 29 in Tokyo, exploring multi-modal photonic computing for real-time, ultra-efficient inference. This work highlights how photonics is reshaping AI performance, enabling faster and more energy-efficient processing across next-generation systems.

Learning to Route: A Rule-Driven Agent Framework for Hybrid-Source Retrieval-Augmented Generation

Large Language Models (LLMs) have shown remarkable performance on general Question Answering (QA), yet they often struggle in domain-specific scenarios where accurate and up-to-date information is required. Retrieval-Augmented Generation (RAG) addresses this limitation by enriching LLMs with external knowledge, but existing systems primarily rely on unstructured documents, while largely overlooking relational databases, which provide precise, timely, and efficiently queryable factual information, serving as indispensable infrastructure in domains such as finance, healthcare, and scientific research. Motivated by this gap, we conduct a systematic analysis that reveals three central observations: (i) databases and documents offer complementary strengths across queries, (ii) naively combining both sources introduces noise and cost without consistent accuracy gains, and (iii) selecting the most suitable source for each query is crucial to balance effectiveness and efficiency. We further observe that query types show consistent regularities in their alignment with retrieval paths, suggesting that routing decisions can be effectively guided by systematic rules that capture these patterns. Building on these insights, we propose a rule-driven routing framework designed specifically for hybrid-source RAG. A routing agent scores candidate augmentation paths based on explicit rules and selects the most suitable one; a rule-making expert agent refines the rules using QA feedback to produce more comprehensive and reliable decision criteria; and a path-level meta-cache reuses past routing decisions for semantically similar queries to reduce latency and cost. Experiments on three QA datasets demonstrate that our framework consistently outperforms static strategies and learned routing baselines, achieving higher accuracy while maintaining moderate computational cost.

Beyond Explainability: How We Are Redefining Interpretability in AI

AI interpretability has long been the focus, but what if it’s only part of the story? New research introduces model semantics, a framework for understanding what AI systems truly represent and how their internal structures connect to real-world phenomena.

Uncertainty-Guided Latent Diagnostic Trajectory Learning for Sequential Clinical Diagnosis

Clinical diagnosis requires sequential evidence acquisition under uncertainty. However, most Large Language Model (LLM) based diagnostic systems assume fully observed patient information and therefore do not explicitly model how clinical evidence should be sequentially acquired over time. Even when diagnosis is formulated as a sequential decision process, it is still challenging to learn effective diagnostic trajectories. This is because the space of possible evidence-acquisition paths is relatively large, while clinical datasets rarely provide explicit supervision information for desirable diagnostic paths. To this end, we formulate sequential diagnosis as a Latent Diagnostic Trajectory Learning (LDTL) framework based on a planning LLM agent and a diagnostic LLM agent. For the diagnostic LLM agent, diagnostic action sequences are treated as latent paths and we introduce a posterior distribution that prioritizes trajectories providing more diagnostic information. The planning LLM agent is then trained to follow this distribution, encouraging coherent diagnostic trajectories that progressively reduce uncertainty. Experiments on the MIMIC-CDM benchmark demonstrate that our proposed LDTL framework outperforms existing baselines in diagnostic accuracy under a sequential clinical diagnosis setting, while requiring fewer diagnostic tests. Furthermore, ablation studies highlight the critical role of trajectory-level posterior alignment in achieving these improvements.

The Best April Fools’ Day Hoaxes by Companies

Every April Fools’ Day, companies push the boundaries of creativity with bold, believable hoaxes. Led by Google, these pranks blend humor with real tech trends, making them both entertaining and surprisingly insightful. Discover the funniest examples and why they resonate so widely.