Data Imputation refers to filling in missing values in spatial transcriptomic data, which arises due to limitations in current measurement technologies. This technique is essential for enhancing the resolution and interpretability of gene expression profiles by estimating and replacing incomplete data points. Effective data imputation helps to create a more complete and accurate representation of the spatiotemporal gene expression landscape and cell interactions, thereby improving the overall analysis without relying on additional matched single-cell RNA-seq data or neglecting spatial and expression similarity information.
We present a generative AI framework based on a conditional diffusion model for distributed acoustic sensing (DAS) data imputation. The proposed DiffOptics model generates high-quality DAS data of various acoustic events using telecom fiber cables.
Recent advances in spatial transcriptomics allow spatially resolved gene expression measurements with cellular or even sub-cellular resolution, directly characterizing the complex spatiotemporal gene expression landscape and cell-to-cell interactions in their native microenvironments. Due to technology limitations, most spatial transcriptomic technologies still yield incomplete expression measurements with excessive missing values. Therefore, gene imputation is critical to filling in missing data, enhancing resolution, and improving overall interpretability. However, existing methods either require additional matched single-cell RNA-seq data, which is rarely available, or ignore spatial proximity or expression similarity information
Cyber-physical systems (CPS) are ubiquitous in several critical infrastructure applications. Forecasting the state of CPS, is essential for better planning, resource allocation and minimizing operational costs. It is imperative to forecast the state of a CPS multiple steps into the future to afford enough time for planning of CPS operation to minimize costs and component wear. Forecasting system state also serves as a precursor to detecting process anomalies and faults. Concomitantly, sensors used for data collection are commodity hardware and experience frequent failures resulting in periods with sparse or no data. In such cases, re-construction through imputation of the missing data sequences is imperative to alleviate data sparsity and enable better performance of down-stream analytic models. In this paper, we tackle the problem of CPS state forecasting and data imputation and characterize the performance of a wide array of deep learning architectures – unidirectional gated and non-gated recurrent architectures, sequence to sequence (Seq2Seq) architectures as well as bidirectional architectures – with a specific focus towards applications in CPS. We also study the impact of procedures like scheduled sampling and attention, on model training. Our results indicate that Seq2Seq models are superior to traditional step ahead forecasting models and yield an improvement of at least 28.5% for gated recurrent architectures and about 87.6% for non-gated architectures in terms of forecasting performance. We also notice that bidirectional models learn good representations for forecasting as well as for data imputation. Bidirectional Seq2Seq models show an average improvement of 17.6% in forecasting performance over their unidirectional counterparts. We also demonstrate the effect of employing an attention mechanism in the context of Seq2Seq architectures and find that it provides an average improvement of 57.12% in the case of unidirectional Seq2Seq architectures while causing a performance decline in the case of bidirectional Seq2Seq architectures. Finally, we also find that scheduled sampling helps in training better models that yield significantly lower forecasting error.
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