Machine LearningOur Machine Learning team has been at the forefront of machine learning developments, including deep learning, support vector machines, and semantic analysis, for over a decade. We develop innovative technologies integrated into NEC’s products and services. Machine learning is the critical technology for data analytics and artificial intelligence. Recent progress in this field opens opportunities for various new applications.

Deep learning will maintain prominence with more robust model architectures, training methods, and optimization techniques. Enhanced interpretability and explainability will be imperative, especially for AI systems in critical domains like healthcare and finance. Addressing bias and ensuring fairness in AI algorithms will be a top priority, leading to the development of tools and guidelines for ethical AI. Federated learning, quantum computing’s potential impact, and the growth of edge computing will diversify ML applications.

Natural language processing will continue to advance, driving progress in conversational AI, while healthcare, finance, education, and creative industries will witness profound AI integration. As quantum computing matures, it could revolutionize machine learning, while edge computing and federated learning will expand AI’s reach across various domains. Our machine learning research will produce innovation across industries, including more accurate medical diagnoses, safer autonomous systems, and efficient energy use while enabling personalized education and AI-generated creativity.

Read our news and publications from our world-class team of researchers from our Machine Learning department.

Posts

Source-Free Video Domain Adaptation with Spatial-Temporal-Historical Consistency Learning

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Source-free domain adaptation (SFDA) is an emerging research topic that studies how to adapt a pretrained source model using unlabeled target data. It is derived from unsupervised domain adaptation but has the advantage of not requiring labeled source data to learn adaptive models. This makes it particularly useful in real-world applications where access to source data is restricted. While there has been some SFDA work for images, little attention has been paid to videos. Naively extending image-based methods to videos without considering the unique properties of videos often leads to unsatisfactory results. In this paper, we propose a simple and highly flexible method for Source-Free Video Domain Adaptation (SFVDA), which extensively exploits consistency learning for videos from spatial, temporal, and historical perspectives. Our method is based on the assumption that videos of the same action category are drawn from the same low-dimensional space, regardless of the spatio-temporal variations in the high-dimensional space that cause domain shifts. To overcome domain shifts, we simulate spatio-temporal variations by applying spatial and temporal augmentations on target videos, and encourage the model to make consistent predictions from a video and its augmented versions. Due to the simple design, our method can be applied to various SFVDA settings, and experiments show that our method achieves state-of-the-art performance for all the settings.

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Towards Realizing the Value of Labeled Target Samples: a Two-Stage Approach for Semi-Supervised Domain Adaptation

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Semi-Supervised Domain Adaptation (SSDA) is a recently emerging research topic that extends from the widely-investigated Unsupervised Domain Adaptation (UDA) by further having a few target samples labeled, i.e., the model is trained with labeled source samples, unlabeled target samples as well as a few labeled target samples. Compared with UDA, the key to SSDA lies how to most effectively utilize the few labeled target samples. Existing SSDA approaches simply merge the few precious labeled target samples into vast labeled source samples or further align them, which dilutes the value of labeled target samples and thus still obtains a biased model. To remedy this, in this paper, we propose to decouple SSDA as an UDA problem and a semi-supervised learning problem where we first learn an UDA model using labeled source and unlabeled target samples and then adapt the learned UDA model in a semi-supervised way using labeled and unlabeled target samples. By utilizing the labeled source samples and target samples separately, the bias problem can be well mitigated. We further propose a consistency learning based mean teacher model to effectively adapt the learned UDA model using labeled and unlabeled target samples. Experiments show our approach outperforms existing methods.

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T-Cell Receptor Optimization with Reinforcement Learning and Mutation Polices for Precision Immunotherapy

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T cells monitor the health status of cells by identifying foreign peptides displayed on their surface. T-cell receptors (TCRs), which are protein complexes found on the surface of T cells, are able to bind to these peptides. This process is known as TCR recognition and constitutes a key step for immune response. Optimizing TCR sequences for TCR recognition represents a fundamental step towards the development of personalized treatments to trigger immune responses killing cancerous or virus-infected cells. In this paper, we formulated the search for these optimized TCRs as a reinforcement learning (RL) problem and presented a framework TCRPPO with a mutation policy using proximal policy optimization. TCRPPO mutates TCRs into effective ones that can recognize given peptides. TCRPPO leverages a reward function that combines the likelihoods of mutated sequences being valid TCRs measured by a new scoring function based on deep autoencoders, with the probabilities of mutated sequences recognizing peptides from a peptide-TCR interaction predictor. We compared TCRPPO with multiple baseline methods and demonstrated that TCRPPO significantly outperforms all the baseline methods to generate positive binding and valid TCRs. These results demonstrate the potential of TCRPPO for both precision immunotherapy and peptide-recognizing TCR motif discovery.

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Explore Benefits of Distributed Fiber Optic Sensing for Optical Network Service Providers

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We review various applications of distributed fiber optic sensing (DFOS) and machine learning (ML) technologies that particularly benefit telecom operators’ fiber networks and businesses. By leveraging relative phase shift of the reflectance of coherent Rayleigh, Brillouin and Raman scattering of light wave, the ambient environmental vibration, acoustic effects, temperature and fiber/cable strain can be detected. Fiber optic sensing technology allows optical fiber to support sensing features in addition to its conventional role to transmit data in telecommunications. DFOS has recently helped telecom operators by adding multiple sensing features and proved feasibility of co-existence of sensing and communication systems on same fiber. We review the architecture of DFOS technique and show examples where optical fiber sensing helps enhance network operation efficiency and create new services for customers on deployed fiber infrastructures, such as determination of cable locations, cable cut prevention, perimeter intrusion detection and networked sensing applications. In addition, edge AI platform allows data processing to be conducted on-the-fly with low latency. Based on discriminative spatial-temporal signatures of different events of interest, real-time processing of the sensing data from the DFOS system provides results of the detection, classification and localization immediately.

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A New Hope: AI Research is Conquering Today’s Computer Vision Plateau

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The age of computer vision is upon us, and it’s transforming the way we live, work and interact with the world. Nearly every industry has found a use case to grow revenue, reduce cost, or create exceptional experiences using computer vision. From self-driving cars to retail automation, surgeons to farmers, computer vision is everywhere, providing critical insights that are driving progress in virtually every aspect of our daily lives. Today, images and videos are annotated to train artificial intelligence (AI) models to recognize specific objects, but there is still so much more to be done when it comes to understanding what those objects are doing in real-time.

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Adversarial Alignment for Source Free Object Detection

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Source-free object detection (SFOD) aims to transfer a detector pre-trained on a label-rich source domain to an unlabeled target domain without seeing source data. While most existing SFOD methods generate pseudo labels via a source-pretrained model to guide training, these pseudo labels usually contain high noises due to heavy domain discrepancy. In order to obtain better pseudo supervisions, we divide the target domain into source-similar and source-dissimilar parts and align them in the feature space by adversarial learning. Specifically, we design a detection variance-based criterion to divide the target domain. This criterion is motivated by a finding that larger detection variances denote higher recall and larger similarity to the source domain. Then we incorporate an adversarial module into a mean teacher framework to drive the feature spaces of these two subsets indistinguishable. Extensive experiments on multiple cross-domain object detection datasets demonstrate that our proposed method consistently outperforms the compared SFOD methods. Our implementation is available at https://github.com/ChuQiaosong

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Binding Peptide Generation for MHC Class I Proteins with Deep Reinforcement Learning

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Motivation: MHC Class I protein plays an important role in immunotherapy by presenting immunogenic peptides to anti-tumor immune cells. The repertoires of peptides for various MHC Class I proteins are distinct, which can be reflected by their diverse binding motifs. To characterize binding motifs for MHC Class I proteins, in vitro experiments have been conducted to screen peptides with high binding affinities to hundreds of given MHC Class I proteins. However, considering tens of thousands of known MHC Class I proteins, conducting in vitro experiments for extensive MHC proteins is infeasible, and thus a more efficient and scalable way to characterize binding motifs is needed.Results: We presented a de novo generation framework, coined PepPPO, to characterize binding motif for any given MHC Class I proteins via generating repertoires of peptides presented by them. PepPPO leverages a reinforcement learning agent with a mutation policy to mutate random input peptides into positive presented ones. Using PepPPO, we characterized binding motifs for around 10 000 known human MHC Class I proteins with and without experimental for the rapid screening of neoantigens at a much lower time cost than previous deep-learning methods.

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Real-time ConcealedWeapon Detection on 3D Radar Images forWalk-through Screening System

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This paper presents a framework for real-time concealed weapon detection (CWD) on 3D radar images for walk-through screening systems. The walk-through screening system aims to ensure security in crowded areas by performing CWD on walking persons, hence it requires an accurate and real-time detection approach. To ensure accuracy, a weapon needs to be detected irrespective of its 3D orientation, thus we use the 3D radar images as detection input. For achieving real-time, we reformulate classic U-Net based segmentation networks to perform 3D detection tasks. Our 3D segmentation network predicts peak-shaped probability map, instead of voxel-wise masks, to enable position inference by elementary peak detection operation on the predicted map. In the peak-shaped probability map, the peak marks the weapon’s position. So, weapon detection task translates to peak detection on the probability map. A Gaussian function is used to model weapons in the probability map. We experimentally validate our approach on realistic 3D radar images obtained from a walk-through weapon screening system prototype. Extensive ablation studies verify the effectiveness of our proposed approach over existing conventional approaches. The experimental results demonstrate that our proposed approach can perform accurate and real-time CWD, thus making it suitable for practical applications of walk-through screening.

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On TCR Binding Predictors Failing to Generalize to Unseen Peptides

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Several recent studies investigate TCR-peptide/-pMHC binding prediction using machine learning or deep learning approaches. Many of these methods achieve impressive results on test sets, which include peptide sequences that are also included in the training set. In this work, we investigate how state of the-art deep learning models for TCR-peptide/-pMHC binding prediction generalize to unseen peptides. We create a dataset including positive samples from IEDB, VDJdb, McPAS-TCR, and the MIRA set, as well as negative samples from both randomization and 10X Genomics assays. We name this collection of samples TChard. We propose the hard split, a simple heuristic for training/test split, which ensures that test samples exclusively present peptides that do not belong to the training set. We investigate the effect of different training/test splitting techniques on the models’ test performance, as well as the effect of training and testing the models using mismatched negative samples generated randomly, in addition to the negative samples derived from assays. Our results show that modern deep learning methods fail to generalize to unseen peptides. We provide an explanation why this happens and verify our hypothesis on the TChard dataset. We then conclude that robust prediction of TCR recognition is still far for being solved.

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Attentive Variational Information Bottleneck for TCR–peptide interaction prediction

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We present a multi-sequence generalization of Variational Information Bottleneck and call the resulting model Attentive Variational Information Bottleneck (AVIB). Our AVIB model leverages multi-head self-attention to implicitly approximate a posterior distribution over latent encodings conditioned on multiple input sequences. We apply AVIB to a fundamental immuno-oncology problem: predicting the interactions between T-cell receptors (TCRs) and peptides.ResultsExperimental results on various datasets show that AVIB significantly outperforms state-of-the-art methods for TCR–peptide interaction prediction. Additionally, we show that the latent posterior distribution learned by AVIB is particularly effective for the unsupervised detection of out-of-distribution amino acid sequences.

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