Deep Learning-Based Real-Time Quality Control of Standard Video Compression for Live Streaming

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Ensuring high-quality video content for wireless users has become increasingly vital. Nevertheless, maintaining a consistent level of video quality faces challenges due to the fluctuating encoded bitrate, primarily caused by dynamic video content, especially in live streaming scenarios. Video compression is typically employed to eliminate unnecessary redundancies within and between video frames, thereby reducing the required bandwidth for video transmission. The encoded bitrate and the quality of the compressed video depend on encoder parameters, specifically, the quantization parameter (QP). Poor choices of encoder parameters can result in reduced bandwidth efficiency and high likelihood of non-conformance. Non-conformance refers to the violation of the peak signal-to-noise ratio (PSNR) constraint for an encoded video segment. To address these issues, a real-time deep learning-based H.264 controller is proposed. This controller dynamically estimates the optimal encoder parameters based on the content of a video chunk with minimal delay. The objective is to maintain video quality in terms of PSNR above a specified threshold while minimizing the average bitrate of the compressed video. Experimental results, conducted on both QCIF dataset and a diverse range of random videos from public datasets, validate the effectiveness of this approach. Notably, it achieves improvements of up to 2.5 times in average bandwidth usage compared to the state-of-the-art adaptive bitrate video streaming, with a negligible non-conformance probability below 10?2.

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Predicting Spatially Resolved Gene Expression via Tissue Morphology using Adaptive Spatial GNNs

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Motivation Spatial transcriptomics technologies, which generate a spatial map of gene activity, can deepen the understanding of tissue architecture and its molecular underpinnings in health and disease. However, the high cost makes these technologies difficult to use in practice. Histological images co-registered with targeted tissues are more affordable and routinely generated in many research and clinical studies. Hence, predicting spatial gene expression from the morphological clues embedded in tissue histological images, provides a scalable alternative approach to decoding tissue complexity

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StreamingRAG: Real-time Contextual Retrieval and Generation Framework

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Extracting real-time insights from multi-modal data streams from various domains such as healthcare, intelligent transportation, and satellite remote sensing remains a challenge. High computational demands and limited knowledge scope restrict the applicability of Multi-Modal Large Language Models (MM-LLMs) on these data streams. Traditional Retrieval-Augmented Generation (RAG) systems address knowledge limitations of these models, but suffer from slow preprocessing, making them unsuitable for real-time analysis. We propose StreamingRAG, a novel RAG framework designed for streaming data. StreamingRAG constructs evolving knowledge graphs capturing scene-object-entity relationships in real-time. The knowledge graph achieves temporal-aware scene representations using MM-LLMs and enables timely responses for specific events or user queries. StreamingRAG addresses limitations in existing methods, achieving significant improvements in real-time analysis (5-6x faster throughput), contextual accuracy (through a temporal knowledge graph), and reduced resource consumption (using lightweight models by 2-3x).

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ECO-LLM: LLM-based Edge Cloud Optimization

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AI/ML techniques have been used to solve systems problems, but their applicability to customize solutions on-the-fly has been limited. Traditionally, any customization required manually changing the AI/ML model or modifying the code, configuration parameters, application settings, etc. This incurs too much time and effort, and is very painful. In this paper, we propose a novel technique using Generative Artificial Intelligence (GenAI) technology, wherein instructions can be provided in natural language and actual code to handle any customization is automatically generated, integrated and applied on-the-fly. Such capability is extremely powerful since it makes customization of application settings or solution techniques super easy. Specifically, we propose ECO-LLM (LLM-based Edge Cloud Optimization), which leverages Large Language Models (LLM) to dynamically adjust placement of application tasks across edge and cloud computing tiers, in response to changes in application workload, such that insights are delivered quickly with low cost of operation (systems problem). Our experiments with real-world video analytics applications i.e. face recognition, human attributes detection and license plate recognition show that ECO-LLM is able to automatically generate code on-the-fly and adapt placement of application tasks across edge and cloud computing tiers. We note that the trigger workload (to switch between edge and cloud) for ECO-LLM is exactly the same as the baseline (manual) and actual placement performed by ECO-LLM is only slightly different i.e. on average (across 2 days) only 1.45% difference in human attributes detection and face recognition, and 1.11% difference in license plate recognition. Although we tackle this specific systems problem in this paper, our proposed GenAI-based technique is applicable to solve other systems problems too.

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LeanContext: Cost-efficient Domain-specific Question Answering Using LLMs

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Question-answering (QA) is a significant application of Large Language Models (LLMs), shaping chatbot capabilities across healthcare, education, and customer service. However, widespread LLM integration presents a challenge for small businesses due to the high expenses of LLM API usage. Costs rise rapidly when domain-specific data (context) is used alongside queries for accurate domain-specific LLM responses. Extracting context from domain-specific data is implemented by a Retrieval Augmented Generation (RAG) approach. One option is to summarize the RAG context by using LLMs and reduce the context. However, this can also filter out useful information that is necessary to answer some domain-specific queries. In this paper, we shift from human-oriented summarizers to AI model-friendly summaries. Our approach, LeanContext, efficiently extracts k key sentences from the context that are closely aligned with the query. The choice of k is neither static nor random; we introduce a reinforcement learning technique that dynamically determines k based on the query and context. The rest of the less important sentences are either reduced using a free open-source text reduction method or eliminated. We evaluate LeanContext against several recent query-aware and query-unaware context reduction approaches on prominent datasets (arxiv papers and BBC news articles, NarrativeQA). Despite cost reductions of 37.29% to 67.81%, LeanContext’s ROUGE-1 score decreases only by 1.41% to 2.65% compared to a baseline that retains the entire context (no summarization). LeanContext stands out for its ability to provide precise responses, outperforming competitors by leveraging open-source summarization techniques. Human evaluations of the responses further confirm and validate this superiority. Additionally, if open-source pre-trained LLM-based summarizers are used to reduce context (into human consumable summaries), LeanContext can further modify the reduced context to enhance the accuracy (ROUGE-1 score) by 13.22% to 24.61%.

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Advancing Sustainability in Global Supply Chains through Agent-based Simulation

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In today’s world, with its complex global supply chains, the difficulties and uncertainties we face offer both challenges and opportunities for making things better, especially in terms of efficiency and sustainability. These challenges grow due to unpredictable events, such as natural disasters, unexpected incidents, and unusual business practices, pushing us towards more advanced modeling methods that focus on reducing risks and enhancing sustainability. In this paper, we present a new agent-based simulation approach that goes beyond the usual limits of supply chain simulations by incorporating sustainability directly into supply chain operations using reinforcement learning (RL) algorithms. We introduce MOGI, a sustainable supply chain simulation system that takes carbon emissions into account in its main operations. Additionally, we examine how effective a multi-agent RL strategy is in dealing with the complex and uncertain nature of supply chains that span multiple levels. By comparing this strategy with traditional heuristic methods, our study looks at how well single versus multiple RL agents can manage risks and improve sustainability in both the beginning and end parts of the supply chain. The results of our experiments show that strategies based on RL are much better than traditional methods at managing risks, making profits, and achieving sustainability goals.

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Evaluating Cellularity Estimation Methods: Comparing AI Counting with Pathologists’ Visual Estimates

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The development of next-generation sequencing (NGS) has enabled the discovery of cancer-specific driver gene alternations, making precision medicine possible. However, accurategenetic testing requires a sufficient amount of tumor cells in the specimen. The evaluation of tumor content ratio (TCR) from hematoxylin and eosin (H&E)-stained images has been found to vary between pathologists, making it an important challenge to obtain an accurate TCR. In this study, three pathologists exhaustively labeled all cells in 41 regions from 41 lung cancer cases as either tumor, non-tumor or indistinguishable, thus establishing a “gold standard” TCR. We then compared the accuracy of the TCR estimated by 13 pathologists based on visual assessment and the TCR calculated by an AI model that we have developed. It is a compact and fast model that follows a fully convolutional neural network architecture and produces cell detection maps which can be efficiently post-processed to obtain tumor and non-tumor cell counts from which TCR is calculated. Its raw cell detection accuracy is 92% while its classification accuracy is 84%. The results show that the error between the gold standard TCR and the AI calculation was significantly smaller than that between the gold standard TCR and the pathologist’s visual assessment (p < 0.05). Additionally, the robustness of AI models across institutions is a key issue and we demonstrate that the variation in AI was smallerthan that in the average of pathologists when evaluated by institution. These findings suggest that the accuracy of tumor cellularity assessments in clinical workflows is significantly improved by the introduction of robust AI models, leading to more efficient genetic testing and ultimately to better patient outcomes.

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Impeller: A Path-based Heterogeneous Graph Learning Method for Spatial Transcriptomic Data Imputation

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Recent advances in spatial transcriptomics allow spatially resolved gene expression measurements with cellular or even sub-cellular resolution, directly characterizing the complex spatiotemporal gene expression landscape and cell-to-cell interactions in their native microenvironments. Due to technology limitations, most spatial transcriptomic technologies still yield incomplete expression measurements with excessive missing values. Therefore, gene imputation is critical to filling in missing data, enhancing resolution, and improving overall interpretability. However, existing methods either require additional matched single-cell RNA-seq data, which is rarely available, or ignore spatial proximity or expression similarity information

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Improving Test-Time Adaptation For Histopathology Image Segmentation: Gradient-To-Parameter Ratio Guided Feature Alignment

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In the field of histopathology, computer-aided systems face significant challenges due to diverse domain shifts. They include variations in tissue source organ, preparation and scanningprotocols. These domain shifts can significantly impact algorithms’ performance in histopathology tasks, such as cancer segmentation. In this paper, we address this problem byproposing a new multi-task extension of test-time adaptation (TTA) for simultaneous semantic, and instance segmentation of nuclei. First, to mitigate domain shifts during testing, weuse a feature alignment TTA method, through which we adapt the feature vectors of the target data based on the feature vectors’ statistics derived from the source data. Second, the ratioof Gradient norm to Parameter norm (G2P) is proposed to guide the feature alignment procedure. Our approach requires a pre-trained model on the source data, without requiringaccess to the source dataset during TTA. This is particularly crucial in medical applications where access to training data may be restricted due to privacy concerns or patient consent. Through experimental validation, we demonstrate that the proposed method consistently yields competitive results when applied to out-of-distribution data across multiple datasets.

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MULAN: Multi-modal Causal Structure Learning and Root Cause Analysis for Microservice Systems

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Effective root cause analysis (RCA) is vital for swiftly restoring services, minimizing losses, and ensuring the smooth operation and management of complex systems. Previous data-driven RCA methods, particularly those employing causal discovery techniques, have primarily focused on constructing dependency or causal graphs for backtracking the root causes. However, these methods often fall short as they rely solely on data from a single modality, thereby resulting in suboptimal solutions. In this work, we propose Mulan, a unified multi-modal causal structure learning method designed to identify root causes in microservice systems. We leverage a log-tailored language model to facilitate log representation learning, converting log sequences into time-series data. To explore intricate relationships across different modalities, we propose a contrastive learning-based approach to extract modality-invariant and modality-specific representations within a shared latent space. Additionally, we introduce a novel key performance indicator-aware attention mechanism for assessing modality reliability and co-learning a final causal graph. Finally, we employ random walk with restart to simulate system fault propagation and identify potential root causes. Extensive experiments on three real-world datasets validate the effectiveness of our proposed method.

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