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On National Intern Day, NEC Laboratories America celebrates the bright minds shaping tomorrow’s technology. Each summer, interns from top universities work side-by-side with our researchers on real-world challenges in AI, cybersecurity, data science, and more. From groundbreaking research to team-building events, our interns contribute fresh ideas and bold thinking that power NEC’s innovation engine.
Motivation: MHC Class I protein plays an important role in immunotherapy by presenting immunogenic peptides to anti-tumor immune cells. The repertoires of peptides for various MHC Class I proteins are distinct, which can be reflected by their diverse binding motifs. To characterize binding motifs for MHC Class I proteins, in vitro experiments have been conducted to screen peptides with high binding affinities to hundreds of given MHC Class I proteins. However, considering tens of thousands of known MHC Class I proteins, conducting in vitro experiments for extensive MHC proteins is infeasible, and thus a more efficient and scalable way to characterize binding motifs is needed.Results: We presented a de novo generation framework, coined PepPPO, to characterize binding motif for any given MHC Class I proteins via generating repertoires of peptides presented by them. PepPPO leverages a reinforcement learning agent with a mutation policy to mutate random input peptides into positive presented ones. Using PepPPO, we characterized binding motifs for around 10 000 known human MHC Class I proteins with and without experimental for the rapid screening of neoantigens at a much lower time cost than previous deep-learning methods.
With over a billion sold each year, cameras are not only becoming ubiquitous, but are driving progress in a wide range of domains such as mixed reality, robotics, and more. However, severe concerns regarding the privacy implications of camera-based solutions currently limit the range of environments where cameras can be deployed. The key question we address is: Can cameras be enhanced with a scalable solution to preserve users’ privacy without degrading their machine intelligence capabilities? Our solution is a novel end-to-end adversarial learning pipeline in which a phase mask placed at the aperture plane of a camera is jointly optimized with respect to privacy and utility objectives. We conduct an extensive design space analysis to determine operating points with desirable privacy-utility tradeoffs that are also amenable to sensor fabrication and real-world constraints. We demonstrate the first working prototype that enables passive depth estimation while inhibiting face identification.
Promising progress has been made toward learning efficient time series representations in recent years, but the learned representations often lack interpretability and do not encode semantic meanings by the complex interactions of many latent factors. Learning representations that disentangle these latent factors can bring semantic-rich representations of time series and further enhance interpretability. However, directly adopting the sequential models, such as Long Short-Term Memory Variational AutoEncoder (LSTM-VAE), would encounter a Kullback?Leibler (KL) vanishing problem: the LSTM decoder often generates sequential data without efficiently using latent representations, and the latent spaces sometimes could even be independent of the observation space. And traditional disentanglement methods may intensify the trend of KL vanishing along with the disentanglement process, because they tend to penalize the mutual information between the latent space and the observations. In this paper, we propose Disentangle Time-Series, a novel disentanglement enhancement framework for time series data. Our framework achieves multi-level disentanglement by covering both individual latent factors and group semantic segments. We propose augmenting the original VAE objective by decomposing the evidence lower-bound and extracting evidence linking factorial representations to disentanglement. Additionally, we introduce a mutual information maximization term between the observation space to the latent space to alleviate the KL vanishing problem while preserving the disentanglement property. Experimental results on five real-world IoT datasets demonstrate that the representations learned by DTS achieve superior performance in various tasks with better interpretability.
Behavior-based Community Detection: Application to Host Assessment in Enterprise Information Networks Community detection in complex networks is a fundamental problem that attracts much attention across various disciplines. Previous studies have been mostly focusing on external connections between nodes (i.e., topology structure) in the network whereas largely ignoring internal intricacies (i.e., local behavior) of each node. A pair of nodes without any interaction can still share similar internal behaviors. For example, in an enterprise information network, compromised computers controlled by the same intruder often demonstrate similar abnormal behaviors even if they do not connect with each other. In this paper, we study the problem of community detection in enterprise information networks, where large-scale internal events and external events coexist on each host. The discovered host communities, capturing behavioral affinity, can benefit many comparative analysis tasks such as host anomaly assessment. In particular, we propose a novel community detection framework to identify behavior-based host communities in enterprise information networks, purely based on large-scale heterogeneous event data. We continue proposing an efficient method for assessing host’s anomaly level by leveraging the detected host communities. Experimental results on enterprise networks demonstrate the effectiveness of our model.
The latent behavior of an information system that can exhibit extreme events, such as system faults or cyber-attacks, is complex. Recently, the invariant network has shown to be a powerful way of characterizing complex system behaviors. Structures and evolutions of the invariance network, in particular, the vanishing correlations, can shed light on identifying causal anomalies and performing system diagnosis. However, due to the dynamic and complex nature of real-world information systems, learning a reliable invariant network in a new environment often requires continuous collecting and analyzing the system surveillance data for several weeks or even months. Although the invariant networks learned from old environments have some common entities and entity relationships, these networks cannot be directly borrowed for the new environment due to the domain variety problem. To avoid the prohibitive time and resource consuming network building process, we propose TINET, a knowledge transfer based model for accelerating invariant network construction. In particular, we first propose an entity estimation model to estimate the probability of each source domain entity that can be included in the final invariant network of the target domain. Then, we propose a dependency construction model for constructing the unbiased dependency relationships by solving a two-constraint optimization problem. Extensive experiments on both synthetic and real-world datasets demonstrate the effectiveness and efficiency of TINET. We also apply TINET to a real enterprise security system for intrusion detection. TINET achieves superior detection performance at least 20 days lead-lag time in advance with more than 75% accuracy.
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NEC Laboratories America, Inc. (NEC Labs) is the US-based center for NEC Corporation’s global network of corporate research laboratories. Our diverse research groups collaborate with industry, academia and governments to provide disruptive solutions to complex problems. A leader in the integration of IT and network technologies with more than 100 years of expertise, NEC provides a combination of products and solutions that cross-utilize the company’s experience and global resources to meet the complex and ever-changing needs of its customers.