Spatially Informed Gene Signatures for Response to Immunotherapy in Melanoma

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Publication Date: 8/15/2024

Event: Clinical Cancer Research

Reference: 30(16):3520-3532, 2024

Authors: Thazin N Aung, Yale University; Jonathan Warrell, NEC Laboratories America, Inc.; Sandra Martinez-Morilla, Yale University; Niki Gavrielatou, Yale University; Ioannis Vathiotis, Yale University; Vesal Yaghoobi, Yale University; Harriet M Kluger, Yale University; Mark Gerstein, Yale University; David L Rimm, Yale University

Abstract: We aim to improve the prediction of response or resistance to immunotherapies in patients with melanoma. This goal is based on the hypothesis that current gene signatures predicting immunotherapy outcomes show only modest accuracy due to the lack of spatial information about cellular functions and molecular processes within tumors and their microenvironment.

Publication Link: https://aacrjournals.org/clincancerres/article-abstract/30/16/3520/746786/Spatially-Informed-Gene-Signatures-for-Response-to?redirectedFrom=fulltext