Tumor Microenvironment (TME) is the complex, dynamic ecosystem surrounding a tumor, including immune cells, stromal cells, blood vessels, signaling molecules, and extracellular matrix, which interact with the tumor cells. Machine learning is used to model, analyze, and predict the interactions within the TME to better understand tumor behavior, progression, and response to therapies.
We aim to improve the prediction of response or resistance to immunotherapies in patients with melanoma. This goal is based on the hypothesis that current gene signatures predicting immunotherapy outcomes show only modest accuracy due to the lack of spatial information about cellular functions and molecular processes within tumors and their microenvironment.
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NEC Laboratories America, Inc. (NEC Labs) is the US-based center for NEC Corporation’s global network of corporate research laboratories. Our diverse research groups collaborate with industry, academia and governments to provide disruptive solutions to complex problems. A leader in the integration of IT and network technologies with more than 100 years of expertise, NEC provides a combination of products and solutions that cross-utilize the company’s experience and global resources to meet the complex and ever-changing needs of its customers.