Subsea cables are critical components of offshore wind turbines and are subjected to scour. Monitoring the scour conditions of subsea cables plays significant roles in improving safety and operation efficiency and reducing the levelized cost of electricity. This paper presents a feasibility study on monitoring subsea cables using distributed fiber optic sensors (DFOS), aiming to evaluate the technical and economic performance of utilizing DFOS to detect, locate, and quantify scour conditions. Laboratory experiments were conducted to test the response ofDFOS measurements to the change of support conditions which were used to simulate scour effects, and a finite element model was developed to investigate the impact of scour on the mechanical responses of subsea cables in different scour scenarios. Economic analysis of three methods, involving the use of DFOS, discrete sensors, and underwater robots, is performed via a case study. The results showed that the proposed method has technical and economic benefits for monitoring subsea cables. This research offers insights into monitoring subsea structuresfor offshore wind turbines.